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(E)-AG 556 is a small-molecule, selective inhibitor of the epidermal growth factor receptor (EGFR) used in preclinical research to probe EGFR-mediated signaling and inflammatory responses. It inhibits EGFR kinase activity and has been reported to reduce LPS-induced TNF-α production. The compound is supplied as a high-purity powder and is also available as a ready-to-use 10 mM stock solution in 1 mL vials for convenient dosing in cellular and biochemical assays.
Selective EGFR inhibitor for signaling studies.
Reported to block LPS-induced TNF-α production in cell assays.
High purity suitable for biochemical and cell-based assays.
Available as powder and as a 10 mM stock solution for immediate use.
Molecular formula C20H20N2O3 and molecular weight 336.39 g/mol.
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Miltex diamond burs come in a variety of shapes and grits for more flexibility for procedures. Diamond particles are uniform in coverage for optimal cutting performance. Crosscut fissure straight. 10 pack. 556.
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(E)-AG 556 is a selective small-molecule inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase used in cell signaling and pharmacology research. It has been shown to inhibit EGFR-dependent signaling and to block lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF-α) production in cellular assays. Supplied as a purified solid, it is typically prepared as DMSO stock solutions for in vitro experiments.
Selective inhibitor of EGFR tyrosine kinase.
Inhibits LPS-induced TNF-α production in cell assays.
High purity suitable for in vitro research applications.
Soluble in DMSO for concentrated stock preparation.
Provided as a solid powder for laboratory use.
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Silicone solution SERVA for siliconizing glass and metal in isopropanol Suitable for siliconizing UV quartz cuvettes. Size - 250ML Storage Conditions - +15 °C TO +30 °C Catalog Number - 35130.03
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Silicon Solution Serva for Siconizing Glass and Metal, 100mL, in isopropanol, Suitable for siliconizing UV quartz cuvettes. Storage Conditions: +15 °C TO +30 °C
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PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM respectively PMX-53 is also an agonist of Mas-related gene 2 (MrgX2)
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PMX-53 is a synthetic peptidic antagonist of the complement C5a receptor (C5aR1/CD88). It is orally active and is used in preclinical research on inflammation, cancer, and atherosclerosis. Reported potency at C5aR1 is approximately 20 nM, and analytical data and storage recommendations are provided with the product documentation.
Peptidic C5a receptor antagonist.
Orally active, suitable for in vivo and in vitro studies.
Potent activity against C5aR1 (IC50 ≈ 20 nM).
Selective for C5aR1 over C5L2 and C3aR.
Characterized sequence and molecular weight for analytical use.
COA available with storage recommendations to preserve stability.
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PMX 205 Trifluoroacetate is a cyclic hexapeptide antagonist targeting the complement C5a receptor (C5aR CD88) It is designed to competitively inhibit C5a binding to its receptor thereby modulating complement-mediated inflammatory pathways PMX 205 Trifluoroacetate exerts its biological activity primarily through competitive antagonism at C5aR reducing downstream inflammatory cellular responses In animal models PMX 205 Trifluoroacetate demonstrates anti-inflammatory effects Based on these pharmacological properties PMX 205 Trifluoroacetate holds research potential in the study of neuroinflammation Alzheimer s disease and chemically induced colitis
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